Disclosed herein is a ketogenic food composition and methods thereof. The ketogenic food composition promotes ketogenesis in a subject in need thereof. The ketogenic food composition includes fat, protein, and carbohydrate. A ratio of fat to a combination of protein and carbohydrate in the ketogenic food composition may be about 2.5:1 to about 4.5:1. The ketogenic food composition may be a sole diet for the subject. Also provided herein is a method of treating a disease in a subject in need thereof. The method includes administering the ketogenic food composition to the subject. The disease may be a cancer or an obesity-related disorder.
