The present application relates to 1,2,3,4,4a,5,6,7-octahydropyrazino[1,2-a][1,4]benzodiazepine, 1,2,3,4,4a,5,6,7-octahydropyrazino[1,2-a][1,5]benzodiazepine, 2,3,4,4a,5,6,7,11b-octahydro-1H-pyrido[3,4-d][2]benzazepine, 1,2,3,4,4a,5,6,7-octahydropyrazino[1,2-a][1]benzazepine, 1,2,3,4,4a,5-hexahydro-7H-pyrazino[1,2-a][4,1]benzoxazepine, and 2,3,4,4a,5,6-hexahydro-1H-pyrazino[2,1-d][1,5]benzoxazepine, and 5,6,7,7a,8,9,10,11-octahydropyrazino[1,2-d]pyrido[3,2-b][1,4]diazepine derivatives of formula (I)wherein R1, R2, R3, R4, R5, R6, X1, X2, X3, X4, Y1, Y2, and Y3are as defined in the specification. The present application also relates to compositions comprising such compounds, and methods of treating disease conditions using such compounds and compositions, and methods for identifying such compounds.本申請案係關於式(I)之1,2,3,4,4a,5,6,7-八氫吡嗪并[1,2-a][1,4]苯并二氮呯、1,2,3,4,4a,5,6,7-八氫吡嗪并[1,2-a][1,5]苯并二氮呯、2,3,4,4a,5,6,7,11b-八氫-1H-吡啶并[3,4-d][2]苯并氮呯、1,2,3,4,4a,5,6,7-八氫吡嗪并[1,2-a][1]苯并氮呯、1,2,3,4,4a,5-六氫-7H-吡嗪并[1,2-a][4,1]苯并噁氮呯及2,3,4,4a,5,6-六氫-1H-吡嗪并[2,1-d][1,5]苯并噁氮呯及5,6,7,7a,8,9,10,11-八氫吡嗪并[1,2-d]吡啶并[3,2-b][1,4]二氮呯衍生物：其中R1、R2、R3、R4、R5、R6、X1、X2、X3、X4、Y1、Y2及Y3係如本說明書中所定義。本申請案亦關於包含該等化合物之組合物，及使用該等化合物及組合物治療疾病病狀之方法，及鑑別該等化合物之方法。
