Gegg, Colin V.,Xiong, Fei,Walker, Kenneth William,Miranda, Leslie P.
申请号：
AU2010201800
公开号：
AU2010201800B2
申请日:
2010.05.05
申请国别(地区):
AU
年份:
2012
代理人:
摘要：
#$%^&*AU2010201800B220120308.pdf#####ABSTRACT Disclosed is a process for preparing a pharmacologically active compound, in which at least one internal conjugation sit of an Fc domain sequence is selected that is amenable to conjugation of an additional functional moiety by a defined conjugation chemistry through 5 the side chain of an amino acid residue at the conjugation site. An appropriate amino acid residue for conjugation may be present in a native Fe domain at the conjugation site or may be added by insertion (i.e., between amino acids in the native Fe domain) or by replacement (i.e., removing amino acids and substituting different amino acids). In the latter case, the number of amino acids added need not correspond to the number of amino acids removed 10 from the previously existing Fc domain. This technology may be used to produce useful compositions of matter and pharmaceutical compositions containing them. A DNA encoding the inventive composition of matter, an expression vector containing the DNA, and a host cell containing the expression vector are also disclosed.
