Nicked polynucleotide complexes for multivalent RNA interference

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专利权人:

Halo-Bio RNAi Therapeutics; Inc.

发明人:

Hauser, Todd M.,Lee, Amy C. H.

申请号：

AU2013202315

公开号：

AU2013202315A1

申请日:

2013.01.03

申请国别(地区):

AU

年份:

2013

代理人:

摘要：

#$%^&*AU2013202315A120130718.pdf#####ABSTRACT OF THE DISCLOSURE The present invention includes multivalent nucleic acid complexes of nucleic acid molecules having two or more target-specific regions, in which the target-specific regions are complementary to a single target gene at more than one distinct nucleotide site, and/or in 5 which the target regions are complementary to more than one target gene or target sequence. One oligonucleotide strand of the complex is nicked and thereby inactivated. Also included are methods of using the complexes for treatment of a variety of diseases and infections. 64

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