The present invention provides a production method of a nicotine transdermal preparation, which is capable of producing a nicotine transdermal preparation conveniently and economically, while maintaining highly precise content uniformity, which is capable of producing a preparation simultaneously achieving fixedness and a soft feeling during adhesion, associated with reduced skin irritation upon peeling off and superior in adhesive property. The present invention provides a nicotine transdermal preparation superior in content uniformity, simultaneously achieving fixedness and a soft feeling during adhesion, and showing reduced skin irritation upon peeling off.The present invention provides a method of producing a preparation containing a support and an adhesive layer formed thereon, which adhesive layer containing nicotine and a liquid ingredient compatible with the adhesive, which method includes (1) providing the adhesive layer wherein a contact angle of nicotine with the adhesive layer before containing nicotine is 20-60°, and (2) applying nicotine to the adhesive layer to allow absorption of nicotine into the adhesive layer, as well as a preparation containing a support and an adhesive layer formed thereon, which adhesive layer including nicotine and a liquid ingredient compatible with the adhesive, wherein a contact angle of nicotine with the adhesive layer before containing nicotine is 20-60°.本發明提供一種尼古丁經皮吸收製劑的製造方法,該方法能夠方便且經濟地製造出尼古丁經皮吸收製劑,同時維持高度精確的含量均一性(content uniformity),該方法能夠製造出在黏著中同時達到固定性和柔軟感覺,伴隨在剝離時減低的皮膚刺激和優良的黏著性質之製劑。本發明提供一種尼古丁經皮吸收製劑,該製劑具有優良的含量均一性,在黏著中同時達到固定性和柔軟感覺,且在剝離時顯示出減低的皮膚刺激性。本發明提供一種製造包含承載體(support)和在其上形成的黏著劑層的製劑之方法,該黏著劑層含有尼古丁及與該黏著劑相容的液體成分,該方法包括(1)提供該黏著劑層,其中在包含尼古丁之前,尼古丁與該黏著劑層的接觸角為20至60°,及(2)將尼古丁施加在該黏著劑層以使尼古丁被吸收到該黏著劑層之內。本發明也提供一種包含承載體和在其上形成黏著劑層的製劑,該黏著劑層含有尼古丁及與該黏著劑相容的液體成分,其中在包含尼古丁之前,尼古丁與該黏著劑層的接觸角為20至60°。
