ELLEN BAXTER,CHRISTOPHER J. CREIGHTON,TIANBAO LU,ALLEN B. REITZ,CHARLES H. REYNOLDS,TINA MORGAN ROSS,ELLEN SIEBER-MCMASTER
申请号:
BRPI0906625
公开号:
BRPI0906625A2
申请日:
2009.01.27
申请国别(地区):
BR
年份:
2015
代理人:
摘要:
The present invention is directed to 6-substituted-thio-2-amino-quinoline derivatives, pharmaceutical compositions containing them and their use in the treatment of Alzheimer's disease (AD), mild cognitive impairment, senility and/or dementia. The compounds of the present invention are inhibitors of &bgr;-secretase, also known as &bgr;-site amyloid cleaving enzyme, BACE, BACE1, Asp2, or memapsin2.