Taro Fujimori;Matthew W. Hruska;Ivan R.S. Correia;Susan Kaye Paulson
发明人:
Ivan R.S. Correia,Taro Fujimori,Matthew W. Hruska,Susan Kaye Paulson
申请号：
US13359250
公开号：
US20120195885A1
申请日:
2012.01.26
申请国别(地区):
US
年份:
2012
代理人:
摘要：
The present invention provides compositions of antibodies, e.g., human antibodies, of varying glycosylation structures that serve to achieve desired rates of serum clearance. The invention also provides methods for modulating the pharmacokinetics of antibodies, e.g., human antibodies, and therapeutic compositions containing such antibodies. These methods rely on varying the glycosylation structures of the antibodies, e.g., human antibodies, to achieve desired rates of serum clearance.
