The present invention is the modulators of pharmacokinetic properties of therapeutic agent, this application provides the compounds of Formulas I, or its pharmaceutically acceptable salt, solvate and/or ester, composition comprising this kind of compound, the treatment method including giving this kind of compound and the treatment method including giving this kind of compound Yu at least one additional therapeutic agent.本發明為治療劑的藥代動力學特性調節劑，本申請提供了式I的化合物，或其藥學上可接受的鹽，溶劑合物和/或酯，包含這類化合物的組合物，包括給予這類化合物的治療方法和包括給予這類化合物與至少一種額外的治療劑的治療方法。
