Use of known or new pyrimidine compounds as an agent for preventing and treating aesthetics skin defect and/or its appendices linked to an imbalance of the differentiation and/or proliferation of epidermal cells
MARAT XAVIER,XAVIER MARAT,MULLER BENOIT,BENOIT MULLER,THOMAS COLLIGNON AGNES,AGNES THOMAS COLLIGNON,BERNARD DOMINIQUE,DOMINIQUE BERNARD
申请号：
FR1255261
公开号：
FR2991680A1
申请日:
2012.06.06
申请国别(地区):
FR
年份:
2013
代理人:
摘要：
Use of an effective quantity of at least pyrimidine compounds (Q) or its salt as an agent for preventing and treating aesthetics skin defect and/or its appendices linked to an imbalance of the differentiation and/or proliferation of epidermal cells, is claimed. Use of an effective quantity of at least pyrimidine compounds (Q) of formulae (I) or (II) or its salt as an agent for preventing and treating aesthetics skin defect and/or its appendices linked to an imbalance of the differentiation and/or proliferation of epidermal cells, is claimed. R1 : H, linear or branched, optionally saturated 1-4C-alkyl or -C(O)R8； R8 : linear or branched, optionally saturated 1-4C-alkyl or phenyl； R2 : H, linear or branched, optionally saturated 1-12C-alkyl group or monovalent group of formula (Ia) or (IIb)； R3-R7 : H, -NO 2, -OH, -OR8, -CN, Br, Cl, I, F, -CF 3, linear or branched, optionally saturated 1-4C-alkyl, phenyl, -OC(O)-R8 or -O-Ph-X； X : H, -OH, -NO 2, F, linear or branched, optionally saturated 1-4C-alkyl or alkoxy； and n : 0, 1 or 2. An independent claim is included for the pyrimidine compounds (Q), where (Q) is different from 5-(3-bromo-phenyl)-1,3-dimethyl-5,7,8,9-tetrahydro-1H-cyclopenta[5,6]pyrido[2,3-d]pyrimidine-2,4,6-trione. [Image] [Image] ACTIVITY : Dermatological； Antipruritic. MECHANISM OF ACTION : None given.La présente invention concerne une utilisation cosmétique, comme agent pour prévenir et/ou traiter un défaut esthétique de la peau et/ou de ses annexes lié à un déséquilibre de la différentiation et/ou de la prolifération des cellules d'un épiderme, d'une quantité efficace d'au moins un composé représenté par une des formules générales (Ia) ou (Ib)
