THE BRIGHAM AND WOMEN'S HOSPITAL, INC.;DANA-FARBER CANCER INSTITUTE, INC.
发明人:
Vijay K. Kuchroo,Sumone Chakravarti,Catherine A. Sabatos-Peyton,Gordon J. Freeman
申请号：
US14464455
公开号：
US09962440B2
申请日:
2014.08.20
申请国别(地区):
US
年份:
2018
代理人:
摘要：
The present invention provides compositions and methods useful for promoting or reducing T-cell trafficking to a target tissue. Also provided are compositions and methods useful for promoting or inhibiting antigen-presenting cell (APC) activation. The invention is related to discovery of functional characteristics of TIM-3, a molecule that is preferentially expressed on the surface of Th1 cells. The methods are useful for treating disorders including cancer, infectious disease, allergy, asthma, and autoimmune disease.
