PROCESS FOR THE SYNTHESIS OF IVABRADINE AS WELL AS PROCESSES FOR THE RESOLUTION OF AMINE AND FOR THE SYNTHESIS OF COMPOUND RELATED TO THE SYNTHESIS OF IVABRADINE
Daniel Brigot,Isaac Gonzalez Blanco,Jean-Michel Lerestif,Jean-Pierre Lecouve
申请号：
BRPI0500480
公开号：
BRPI0500480B1
申请日:
2005.02.17
申请国别(地区):
BR
年份:
2020
代理人:
摘要：
process for the synthesis of (1s) -4,5-dimethoxy -1- (methylaminomethyl) -benzocyclobutane and its addition salts, and application in the synthesis of ivabradine and its addition salts with a pharmaceutically acceptable acid. the present invention relates to a process for the synthesis of the compound of formula (i): and application in the synthesis of ivabradine, addition salts thereof with a pharmaceutically acceptable acid, and hydrates thereof.processo para a síntese de (1s)-4,5-dimetóxi -1-(metilaminometil)-benzociclobutano e sais de adição deste, e aplicação na síntese de ivabradina e sais de adição desta com um ácido farmaceuticamente aceitável. a presente invenção refere-se a um processo para a síntese do composto de fórmula (i): e aplicação na síntese de ivabradina, sais de adição desta com um ácido farmaceuticamente aceitável, e hidratos desta.
