Provided is a medicinal agent or a treatment method, in which a combination of an SGLT2 inhibitor and an anti-hypertension drug is used, and which is useful for the treatment of such diseases that at least hypertension or diabetes is included as a risk factor for a cardiovascular event. According to the present invention, an excellent hypotensive effect, which cannot be achieved when an anti-hypertension drug is used alone, can be achieved. Therefore, the conventional problem of using at least two types of anti-hypertension drugs for achieving a desired hypotensive effect can be solved. Furthermore, the present invention exerts a significant therapeutic effect on diabetes, a diabetes-related disease or a diabetes complication, particularly diabetic nephropathy. Furthermore, the present invention is also useful for the treatment of a disease in which the renal function is deteriorated.本發明係提供一種藉由SGLT2抑制劑與抗高血壓藥之組合，適用於治療至少包含作為心血管事件(Cardiovascular events)之風險因子之高血壓或糖尿病之疾病之醫藥或治療方法。因為依據本發明，可發揮以抗高血壓藥單劑所不能得到之優異的降壓效果，所以可解除至今為達成降壓目標而使用2種以上抗高血壓藥之問題。另外，本發明係於糖尿病、糖尿病相關疾病或糖尿病合併症，尤其糖尿病性腎病，顯示明顯的治療效果。進而，本發明亦適用於治療腎功能降低之疾病。
