COIT, DORIS,HOUGHTON, MICHAEL,MCCOIN, COLIN,MEDINA-SELBY, ANGELICA,VAJDY, MICHAEL
申请号：
CA2630220
公开号：
CA2630220C
申请日:
2006.11.22
申请国别(地区):
CA
年份:
2020
代理人:
摘要：
Immunogenic compositions that elicit immune responses against Norovirus andSapovirus antigens are described.In particular, the invention relates to polynucleotides encoding one or morecapsid proteins or other immunogenic viral polypeptidesfrom one or more strains of Norovirus and/or Sapovirus, coexpression of suchimmunogenic viral polypeptides with adjuvants, andmethods of using the polynucleotides in applications including immunizationand production of immunogenic viral polypeptides andviral-like particles (VLPs). Methods for producing Norovirus- or Sapovirus-derived multiple epitope fusion antigens or polyproteinsand immunogenic compositions comprising one or more immunogenic polypeptides,polynucleotides, VLPs, and/or adjuvants arealso described. The immunogenic compositions of the invention may also containantigens other than Norovirus or Sapovirus antigens,including antigens that can be used in immunization against pathogens thatcause diarrheal diseases, such as antigens derivedfrom rotavirus.
