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IMPROVED DISSOLUTION STABILITY OF CALCIUM CARBONATE TABLETS
专利权人:
发明人:
申请号:
HK12103237.3
公开号:
HK1162354A
申请日:
2012.04.02
申请国别(地区):
HK
年份:
2012
代理人:
摘要:
The present invention relates to a method for the preparation of a tablet comprising at least 50% w/w of calcium carbonate, the method comprising i) providing a particulate composition comprising a) calcium carbonate, b) a binding sugar alcohol selected from sorbitol or isomalt, or combinations thereof, c) a non-binding sugar alcohol selected from mannitol, maltitol or xylitol, or combinations thereof, and ii) compressing said composition using a tabletting machine equipped with at least one pair of punches and dies, wherein the pair of punches and die before filling the die with said particulate composition is sprayed with a composition comprising a lubricant selected from magnesium stearate, calcium stearate or stearic acid or combinations thereof.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/
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