PHARMACEUTICAL COMPOSITIONS OF DONEPEZIL HAVING SPECIFIC IN VITRO DISSOLUTION PROFILE OR PHARMACOKINETICS PARAMETERS

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专利权人:

LUPIN LIMITED

发明人:

BAKHLE, DHANANJAY SADASHIV,SHAH, CHIRAG ANILKUMAR,GADVE, SNEHAL AMEET,SHARMA, NEHA,CHANDRAN, SAJEEV,DESHMUKH, ASHISH ASHOKRAO

申请号：

CA2902665

公开号：

CA2902665A1

申请日:

2014.02.27

申请国别(地区):

CA

年份:

2014

代理人:

摘要：

A timed release pharmaceutical composition comprising donepezil is provided, wherein the composition exhibits the in vitro dissolution profile when tested in a Paddle dissolution apparatus at 50 rpm in 900 ml 6.8 buffer at 37°C, less than about 20% w/w of donepezil is released in 3 to 6 hrs, and more than 90% w/w of donepezil is released after 12 hrs.

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