NATIONAL UNIVERSITY CORPORATION NAGOYA INSTITUTE OF TECHNOLOGY;ORTHOREBIRTH CO., LTD.
发明人:
Toshihiro Kasuga,Yasutoshi Nishikawa
申请号：
US16840309
公开号：
US20200289703A1
申请日:
2020.04.03
申请国别(地区):
US
年份:
2020
代理人:
摘要：
A bone-regeneration material that contains calcium phosphate particles in a biodegradable fiber containing PLGA by using electrospinning. A PLGA resin is heated in a kneader to soften until the viscosity of the resin becomes 102 to 107 Pa·s. A powder of calcium phosphate fine particles is added and mixed with the softened PLGA resin, while the blade of the kneader rotates. The mixture is kneaded by applying thermal and mechanical energy to the mixture through the continuous rotation of the blade of the kneader in the heated state, and aggregations of the calcium phosphate fine particles are disintegrated to prepare a composite in which the calcium phosphate fine particles are dispersed in the PLGA resin. The composite is dissolved in a solvent to prepare a spinning solution. Electrospinning is performed on the spinning solution to manufacture biodegradable fibers having therein the calcium phosphate fine particles substantially uniformly dispersed.
