Lance A. Liotta,Virginia Espina,Rosa I. Gallagher,Kirsten Edmiston
申请号：
US13258119
公开号：
US20120077843A1
申请日:
2010.03.29
申请国别(地区):
US
年份:
2012
代理人:
摘要：
Described herein are progenitor cancer cells and cell lines isolated from human breast ductal carcinoma in situ (DCIS) lesions and the uses of these cells or cell lines in drug design, drug screening, and monitoring in vivo therapy. The DCIS malignant precursor cells or cell lines are epithelial in origin, are positive for markers of autophagy, show at least one genetic difference from normal cells of said fragment, form 3-D tube-like structures or ball aggregates, or are inhibited in formation of 3-D structures and migration by treatment with chloroquine.
