PHARMACEUTICAL COMPOSITION COMPRISING HEXENE FRACTION FRACTIONATED FROM ETHANOL EXTRACT OF ABELIOPHYLLUM DISTICHUM AS AN EFFECTIVE COMPONENT FOR PREVENTION OR TREATMENT OF THROMBOSIS AND HEALTH FUNCTIONAL FOOD COMPRISING THE SAME
SOONCHUNHYANG UNIVERSITY INDUSTRY ACADEMY COOPERATION FOUNDATION;순천향대학교 산학협력단;안동대학교 산학협력단;ANDONG NATIONAL UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION
发明人:
SOHN HO YONG,손호용,KIM YONG SIK,김용식
申请号：
KR1020180006581
公开号：
KR1020190088259A
申请日:
2018.01.18
申请国别(地区):
KR
年份:
2019
代理人:
摘要：
The present invention relates to an antithrombotic composition comprising a hexene fraction of an Abeliophyllum distichum ethanol extract as an active ingredient, and more specifically, to a pharmaceutical composition and a health functional food for preventing or treating/alleviating thrombosis through blood coagulation inhibition comprising a hexene fraction of an ethanol extract prepared from leaves and stems of Abeliophyllum distichum as the active ingredient. As proved through an embodiment of the present specification, the hexene fraction of the Abeliophyllum distichum ethanol extract as the active ingredient of a pharmaceutical composition and a health functional food for prevention or treatment of thrombosis is expected to be used for the purpose of preventing and treating thrombosis such as ischemic stroke or hemorrhagic stroke through improvement of blood circulation since the hexene fraction of the Abeliophyllum distichum ethanol extract not only exhibits strong antithrombotic activity due to inhibition of thrombus formation-related enzymes and inhibition of blood coagulation factors, but also has excellent thermal stability and does not exhibit a loss in an inhibition effect on thrombus formation-related enzymes and blood coagulation factors even in an acidic condition of pH 2 and in blood plasma. Therefore, the present invention is very useful in pharmaceutical and food industries since the active ingredient is processed in various forms such as extract, powder, pill, tablet, and the like to be prepared in forms which can be taken at any time.본 발명은 미선나무(Abeliophyllumdistichum) 에탄올 추출물의 헥센 분획물을 유효성분으로 함유하는 항혈전 조성물에 관한 것으로서, 보다 상세하게는, 미선나무의 잎과 줄기로부터 조제된 에탄올 추출물의 헥센 분획물을 유효성분으로 함유하는 혈액 응고 저해를 통한 혈전증의 예방 또는 치료/개선용 약학적 조성물 및 건강 기능 식품에 관한 것이다. 본 발명의 혈전증의 예방 또는 치료용 약학적 조성물 및 건강 기능 식품의 유효성분으로서의 미선나무 에탄올 추출물의 헥센 분획물은, 본 명세서의 실시예를 통해 증명된 바와 같이, 혈전 생성 관련 효소 저해 및 혈액 응고 인자의 저해에 의한 강력한 항혈전 활성을 나타냄과 동시에, 열 안정성이 우수하고, pH 2의 산성 조건 및 혈장 내에서도 혈전 생성 관련 효소 및 혈액 응고 인자 저해 효과의
