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CONJUGATED ANTIMICROBIAL AGENTS
专利权人:
Technion Research & Development Foundation Limited
发明人:
Timor BAASOV,Varvara Pokrovskaya,Valery Belakhov,Mariana Hainrichson
申请号:
US14461494
公开号:
US20140357591A1
申请日:
2014.08.18
申请国别(地区):
US
年份:
2014
代理人:
摘要:
Provided herein are antimicrobial conjugates of two antibiotic agents, exhibiting improved activity also against resistant bacteria, compared to each of the agents separately or their mixture, and having substantially no resistance emerged thereagainst, as well as processes for preparation the same, compositions containing the same, and uses thereof in medical treatments against pathogenic microorganisms. The disclosed antimicrobial conjugates are composed of aminoglycosides and non-ribosomal active antibiotics. Some of the antimicrobial conjugates are prepared via “click” chemistry.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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