Mann, Lary W.,Leahy, James W.,Nuss, John,Epshteyn, Sergey,Schnepp, Kevin Luke,Noguchi, Robin Tammie,Chen, Jeff,Ibrahim, Mohamed Abdulkader,Dalrymple, Lisa Esther,Shi, Xian,Williams, Matthew Alan,Ridgw
申请号：
AU2005322855
公开号：
AU2005322855B2
申请日:
2005.12.28
申请国别(地区):
AU
年份:
2012
代理人:
摘要：
The invention provides compounds and methods for inhibition of kinases, morespecifically IGF 1 R kinases. The invention also provides compounds and methodsfor inhibition of wildtype Abl. The invention provides compounds formodulating protein kinase enzymatic activity for modulating cellular activitiessuch as proliferation, differentiation, programmed cell death, migrationand chemoinvasion. Compounds of the invention inhibit, regulate and/or modulatekinase receptor signal transduction pathways related to the changes in cellularactivities as mentioned above, and the invention includes compositions whichcontain these compounds, and methods of using them to treat kinase-dependentdiseases and conditions. A compound of formula (I), or a farmaceutically acceptablesalt, hydrate, or prodrug thereof, wherein, V is NRR,or O-R, wherein X is H, halo, C-C alkyl, NO,mono-, di-, or tri-halo substituted methyl, NRR,.C(O)O-C-C alkyl, or N(R)-C(O)-C-Calkyl； Y is H, halo, OH, C-C alkyl, C-Calkyl-NR,R, NRR,, C-Calkoxy, -N(R)-(CH)NRR,-C(O)O-C-C alkyl, -O-(CH)-NRR,-C(O)-C-C alkyl, -C-C-alkyl-R,-O-R, -C(O)-R, -O-(CH)-R,-C(O)-NRR, -C(O)-N(R)-aryl, -C(O)-N(R)(CH)-NRR,-C(O)-N(R)-(CH)-aryl -C(O)-N(R)-(CH)-heterocyclyl；or X and Y together with the atoms to which they are attached form a 4-7 memberedheterocyclyl or heteroaryl group containing one or two heteroatoms independentlyselected from O, N, and S. Z is H, NRR, -S-R,or -0-R
