AHMAD, Saleem,BATT, Douglas G.,LIU, Qingjie,MACOR, John E.,MAISHAL, Tarun Kumar,NAIR, Satheesh Kesavan,TINO, Joseph A.,WATTERSON, Scott Hunter
申请号：
TN2017000158
公开号：
TN2017000158A1
申请日:
2015.10.23
申请国别(地区):
TN
年份:
2018
代理人:
摘要：
Disclosed are compounds of Formula (I): or a salt thereof, wherein Q, R<；sub>；1a <；/sub>；, R<；sub>；1b <；/sub>；, R<；sub>；2a <；/sub>；, R<；sub>；2b <；/sub>；,R<；sub>；3<；/sub>；, R<；sub>；4 <；/sub>；,R<；sub>；5a<；/sub>；, R<；sub>；5b <；/sub>；, R<；sub>；6a<；/sub>；,R<；sub>；6c<；/sub>；, R<；sub>；7a<；/sub>；, R<；sub>；7b <；/sub>；, R<；sub>；7c<；/sub>；, and R<；sub>；7d<；/sub>； are defined herein. Also disclosed are methods of using such compounds as inhibitors of Bruton's tyrosine kinase (Btk), and pharmaceutical compositions comprising such compounds. These compounds are useful in treating, preventing, or slowing the progression of diseases or disorders in a variety of therapeutic areas, such as autoimmune diseases and vascular disease.
