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Oxadiazolidinedione compound
专利权人:
Astellas Pharma Inc.
发明人:
Yoshida, Shigeru,Yonetoku, Yasuhiro,Ohnuki, Kei,Kurosaki, Toshio,Soga, Takatoshi,Negoro, Kenji,Asai, Norio,Iwasaki, Fumiyoshi
申请号:
AU2007241759
公开号:
AU2007241759B2
申请日:
2007.04.23
申请国别(地区):
AU
年份:
2012
代理人:
摘要:
[PROBLEMS] To provide a compound which can be used as a pharmaceutical agent, particularly an insulin secretion enhancer or a prophylactic/therapeutic agent for a disease associated with GPR40 such as diabetes. [MEANS FOR SOLVING PROBLEMS] It is found that an oxadiazolidinedione compound having, at the 2-position of an oxadiazolidinedione ring, a substituent (e.g., a benzyl) bound to a cyclic group through a linker, or a pharmaceutically acceptable salt thereof has an excellent GPR40 agonistic activity. The oxadiazolidinedione compound shows an excellent insulin secretion enhancing effect and an excellent anti-hyperglycemic effect, and therefore is useful as an insulin secretion enhancer or a prophylactic/therapeutic agent for diabetes.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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