PROBLEM TO BE SOLVED: To provide a nucleic acid antibiotic derivative having antibacterial active effect.SOLUTION: This invention provides a compound exhibiting antibacterial activity, more preferably an antibacterial nucleoside compound that exhibits antibacterial activity by inhibiting the action of MraY, and particularly, a novel derivative of Pacidamycin that is MraY inhibitor. This invention provides a novel derivative of Pacidamycin or pharmacologically acceptable salt thereof. This invention provides total synthesis of natural product Pacidamycin D and a derivative thereof.【課題】抗菌活性効果を有する核酸抗生物質誘導体を提供する。【解決手段】抗菌活性を示す化合物、より好ましくはＭｒａＹの作用を阻害することによって抗菌活性を示す抗菌ヌクレオシド化合物、特にＭｒａＹ阻害剤であるＰａｃｉｄａｍｙｃｉｎの新規誘導体。Ｐａｃｉｄａｍｙｃｉｎの新規誘導体またはその薬学的に許容される塩。また、天然物Ｐａｃｉｄａｍｙｃｉｎ Dおよびその誘導体の全合成。【選択図】なし
