This invention provides methods and compositions of antibody therapeutics that are therapeutically effective in the digestive tract or below the mucosal barrier of the digestive tract but do not deliver levels of antibody to the systemic circulation that have been shown to be necessary for clinical benefit following systemic administration of antibody. This invention further describes therapeutic compositions of antibody therapeutics that are therapeutically effective in the digestive tract or below the mucosal barrier of the digestive tract but do no deliver levels of antibody to the systemic circulation that have been associated with adverse events and systemic immunosuppression following systemic administration of antibody.本発明は、消化管内または消化管の粘膜関門下で治療的に有効であるが、抗体の全身投与後に臨床的有用性のために必要であることが示されている抗体のレベルを体循環へ送達しない抗体治療の方法および組成物を提供する。本発明はさらに、消化管内または消化管の粘膜関門下で治療的に有効であるが抗体の全身投与後の、有害事象および全身免疫抑制と関連する抗体のレベルを体循環へ送達しない抗体治療の治療組成物を提供する。【選択図】図１
