Immunogenic composition allows to raise an immune response to a pathogen, particularly viral glycoprotein, which comprises an antigenic glycoprotein of the pathogen, which is at least partially glycosylated glycosylation site； and a useful Vaccine to Immunize Mammal (Div. Sun. No 2354 - 11).
WONG CHI-HUEY,MA CHE,WANG CHENG-CHI,CHEN, JUINE-RUEY
申请号：
CL2014002415
公开号：
CL2014002415A1
申请日:
2014.09.12
申请国别(地区):
CL
年份:
2015
代理人:
摘要：
Immunogenic compositions comprising partially glycosylated viral glycoproteins for use as vaccines against viruses are provided. Vaccines formulated using mono-, di-, or tri-glycosylated viral surface glycoproteins and polypeptides provide potent and broad protection against viruses, even across strains. Pharmaceutical compositions comprising monoglycosylated hemagglutinin polypeptides and vaccines generated therefrom and methods of their use for prophylaxis or treatment of viral infections are disclosed. Methods and compositions are disclosed for influenza virus HA, NA and M2, RSV proteins F, G and SH, Dengue virus glycoproteins M or E, hepatitis C virus glycoprotein E1 or E2 and HIV glycoproteins gp120 and gp41.<；p>；una composició；n inmunogé；nica que permite aumentar la respuesta inmunitaria a una glicoproteí；na de superficie viral que comprende: una glicoproteí；na de superficie viral o sufragmento inmunoló；gicamente activo del mismo, en el que la glicoproteí；na de superficie viral o su fragmento inmunoló；gicamente activo comprende un glicano unido a un sitio de glicosilació；n del mismo, en el que el glicano esta constituido por uno, dos o tres residuos de azú；car y en donde la glicoporteí；na de superficie viral.<；/p>；
