The present invention relates to a series of novel compounds, methods to prevent or treat viral infections in animals by using the novel compounds and to said novel compounds for use as a medicine, more preferably for use as a medicine to treat or prevent viral infections, particularly infections with RNA viruses, more particularly infections with viruses belonging to the family of the Flaviviridae, and yet more particularly infections with the Dengue virus. The present invention furthermore relates to pharmaceutical compositions or combination preparations of the novel compounds, to the compositions or preparations for use as a medicine, more preferably for the prevention or treatment of viral infections. The invention also relates to processes for preparation of the compounds.本發明係關於一系列新穎化合物,使用該等新穎化合物預防或治療動物之病毒感染的方法,及該等新穎化合物用作醫藥、更佳用作治療或預防病毒感染(特定言之,RNA病毒感染,更特定言之,屬於黃病毒科之病毒的感染,且仍更特定言之,登革熱病毒(Dengue virus)感染)之醫藥的用途。本發明此外係關於該等新穎化合物的醫藥組合物或組合製劑、該等組合物或製劑用作醫藥、更佳用於預防或治療病毒感染之用途。本發明亦關於製備該等化合物之方法。