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Compounds useful in the inhibition of il-17 and IFN - G for the treatment of autoimmune inflammation
专利权人:
4SC DISCOVERY GMBH
发明人:
DR. LEBAN JOHANN,DR. TASLER STEFAN,DR. SAEB WAEL,DR. CHEVRIER CARINE
申请号:
ARP120100295
公开号:
AR085038A1
申请日:
2012.01.30
申请国别(地区):
AR
年份:
2013
代理人:
摘要:
Compounds of the General formula (1) and to pharmaceutically acceptable salts or solvates thereof can be used as anti-inflammatory agents and immunomodulators.Claim 1: wherein is a compound of the General formula (1) and to pharmaceutically acceptable salts or solvates thereof, wherein R1 is aryl, heteroaryl or alkyl, cycloalkyl, heterociclilo, which can be substituted with one or more substituents R; ar is aryl, cycloalkyl, Heterociclilo or heteroaryl, which can be substituted with one or more substituents R; Z is aryl,Heteroaryl, cycloalkyl or heterociclilo, which can be substituted with one or more substituents R and haloalquilo is H, alkyl, halogen, or a alquil u00e9ster, which can be substituted with one or more substituents R and R independently represents h, - CO2R, conhr Cro -, -, - so2n (2, r) - so2nhr ID haloalquilo, co, NO2, SO2 haloalquilo - ID, - nrso2 alkyl, alkyl - SO2 -, alkyl - Nr - CO, CNAlkyl, cycloalkyl, aminoalquilo, alquilamino, alkoxy, - Oh, - SH, Alquiltio, hidroxialquilo, hidroxialquilamino, halogen, haloalquilo, haloalcoxi, amino, heterociclilo, aryl, heteroaryl haloarilo, haloarilalquilo, arylalkyl or independently; R represents h, haloalquilo, hidroxialqui So, alkoxy, amino - n = C 2 (R) - Nr - CO - R, - Cro - CO2R, alkyl, cycloalkyl, aryl, haloarilo,Haloarilalquilo, heteroaryl, heterociclilo, arylalkyl or aminoalquilo, which are optionally substituted with one or more substituents R.Compuestos de la formula general (1) y sales o solvatos farmacéuticamente aceptables de éstos que pueden usarse como agentes antiinflamatorios e inmunomoduladores.Reivindicación 1: Un compuesto caracterizado porque es de la fórmula general (1) y sales aceptables farmacéuticamente o solvatos del mismo, donde R1 es arilo, heteroarilo, cicloalquilo, heterociclilo o alquilo, que puede estar sustituido con uno o más sustituyentes R’; Ar es arilo, cicloalquilo, heterociclilo o heteroarilo, que puede estar sustituido con uno o más sustituyentes R’; Z es
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