РОССИН Раффаэлла (NL),ЛАППХЕН Тильман (NL),ВАН ДЕН БОС Сандра Мартина (NL),РОБИЛЛАРД Марк Стефан (NL),ВЕРСТЕГЕН Ронни Матье (NL)
申请号：
RU2013133813/15
公开号：
RU2013133813A
申请日:
2011.12.16
申请国别(地区):
RU
年份:
2015
代理人:
摘要：
1. A combination for administration, which is administered to a subject and outputting means which is administered to a subject for removing circulating means for introducing the blood from a subject, where the means for introducing comprises a first reactive group, and wherein the deducing means includes a second reactive group, said first and second reactive groups are bio-orthogonal reactive groups, selected so that they were the bio-orthogonal reactive with respect to the core of each Gu, where one of the bio-orthogonal reactive group is a dienophile, and another - diene, where the dienophile is a dienophile to 8-membered ring, which corresponds to the formula (1): wherein each R independently represents H or not more than six cases substituent selected from the group consisting of alkyl, aryl, O-aryl, O-alkyl, S-aryl, S-alkyl, S (O) -aryl, S (O) -alkyl, S (O) -aryl, S (O) alkyl, Si-aryl, Si-alkyl, Si-O-alkyl, OCO-alkyl, OCO-aryl, SCO-alkyl, SCO-aryl, OCS-alkyl, OCS-aryl, SCS-alkyl, SCS- aryl, F, Cl, Br, I, N, SOH, SOH, SOH, POH, RON, OH, SH, NO, NO, CN, OCN, SCN, NCO, NC S, CF, NRR ", wherein each R and R" is independently H or alkyl, aryl, C (= O) O-alkyl, C (= O) O-aryl, C (= S) O- alkyl, C (= S) O-aryl, C (= O) S-alkyl, C (= O) S-aryl, C (= S) S-alkyl, C (= S) S-aryl, C (= O) NRR ", wherein each R and R" independently is H, aryl or alkyl, NRCO-alkyl, wherein R is H, alkyl or aryl, NRCO-aryl, wherein R is H, alkyl or aryl, NRC (= O) O-alkyl, wherein R is H, alkyl or aryl, NRC (= O) O-aryl, wherein R is H, alkyl or aryl , OCONR-alkyl, wherein R is H, alkyl or aryl, OCONR-aryl, wherein R is H, alkilo
