INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION
发明人:
DIMARCHI, RICHARD D.,SMILEY, DAVID L.
申请号：
PE0028632013
公开号：
PE07242014A1
申请日:
2012.06.12
申请国别(地区):
PE
年份:
2014
代理人:
摘要：
Refers to a Peptide comprising the Amino Acid Sequence SEQ ID number: 17 or a variant of that Peptide whose Amino Acid Sequence is 85% to 95% identical to the peptide.Where the variant comprising: i) an amino acid at position 10 acilado or rented (ii) an amino acid acilado or rented is replaced with the corresponding amino acid of natural glucagon (SEC ID number: 1) in this position (iii) a Hydrophilic amino acid is covalently bound to a rest in The position 24 (iv) an amino acid is covalently bound to a Hydrophilic which is replaced with the restThe corresponding amino acid natural glucagon (SEC ID number: (1) in such a position, where the rest is Hydrophilic polyethylene glycol (V) the end comprises an amide amino acid C instead of an Alpha Amino Acid carboxylate or (VI) in any of the positions 1 to 29 is replaced with a Minoacido corresponding natural glucagon (SEC ID number: 1) in this position.It also refers to a conjugate comprising a Peptide or a Peptide with other heterologous Variant that exhibits a better activity in the glp-1 receptor compared with natural glucagon, and a Pharmaceutical composition. Said Peptide or Peptide Variant is useful in the treatment of diabetes, metabolic syndrome, ObesitySE REFIERE A UN PEPTIDO QUE COMPRENDE LA SECUENCIA DE AMINOACIDOS DE SEQ ID N�: 17 O UNA VARIANTE DE DICHO PEPTIDO CUYA SECUENCIA DE AMINOACIDOS ES DE 85% A 95% IDENTICA A DICHO PEPTIDO, EN DONDE LA VARIANTE COMPRENDE: i) UN AMINOACIDO ACILADO O ALQUILADO EN LA POSICION 10 ii) UN AMINOACIDO ACILADO O ALQUILADO QUE SE REEMPLAZA CON EL AMINOACIDO CORRESPONDIENTE DEL GLUCAGON NATURAL (SEC ID N�: 1) EN DICHA POSICION iii) UN AMINOACIDO UNIDO COVALENTEMENTE A UN RESTO HIDROFILICO EN LA POSICION 24 iv) UN AMINOACIDO UNIDO COVALENTEMENTE A UN RESTO HIDROFILICO QUE SE REEMPLAZA CON EL AMINOACIDO CORRESPONDIENTE DEL GLUCAGON NATURAL (SEC ID N�: 1) EN DICHA POSICION, EN DONDE EL RESTO HIDROFILICO ES POLIETILENGLICOL v) EL AMINOACIDO DEL EXTREMO C COMPRENDE UNA AMIDA EN LUG
