Combination of urea and isoleucine for Sequential Administration simultaneously or separately for use in the Prevention and / or treatment of a skin Disorder that is reinforced in the endogenous production of antimicrobial peptides in the skin. This also provides topical compositions comprising an effective amount of a combination of urea and isoleucine.Claim 2: The combination for use according to claim 1, in which the antimicrobial cathelicidin peptides are lactoferricina, B - defensin, or combinations thereof.Claim 13: the topical composition for use according to claim 11 - 12, which also includes at least one Compound selected from the group consisting of sunscreen agents, g-linolenic acid, retinol, Coenzyme Q10, Ectoin, cholesterol, calcium, corticoster OIDs, antifungals, vitamins in the Vitamin D Group, and mixtures thereof.Claim 14: the topical composition for use according to claim 11 - 13, which also comprises at least one Compound selected from the group consisting of water, Isopropyl Myristate, Liquid paraffin, Glyceryl Stearate, peg-40 Stearate, sorbitol, etilh Exanoato of cetearilo, Cetyl Alcohol, Dimethicone, Persea gratissima, Stearic acidCarbomer, SODIUM ACRYLATE, Methyl Paraben, Propyl Paraben, Allantoin, lactic acid, perfume, 2 - bromo - 2-nitropropane - 1,3 diol, limonene, hexilcinnamal, isometil - Ionone, 10 - linalool, Benzyl Salicylate and Hydroxy citronellal, citral, eugenol, and mixtures thereof.Combinación de urea e isoleucina para la administración secuencial, simultánea o separada para su uso en la prevención y/o tratamiento de un trastorno cutáneo que se beneficia de un potenciamiento en la producción de péptidos antimicrobianos endógenos en la piel. La presente proporciona además composiciones tópicas que comprenden una cantidad eficaz de una combinación de urea e isoleucina. Reivindicación 2: La combinación para su uso según la reivindicación 1, en la cual los péptidos antimicrobianos son catelicidina, b-defensina, lactoferricina o com
