The Council of the Queensland Institute of Medical Research
发明人:
Khanna, Rajiv
申请号：
AU2012227280
公开号：
AU2012227280A1
申请日:
2012.09.24
申请国别(地区):
AU
年份:
2012
代理人:
摘要：
#$%^&*AU2012227280A120121011.pdf#####46 ABSTRACT An isolated protein construct comprises a polyepitope derived from multiple human cytomegalovirus protein antigen epitopes conjugated to an extracellular domain of glycoprotein B, which isolated protein is capable of eliciting a cytotoxic T5 lymphocyte immune response as well as a neutralizing antibody response to human cytomegalovirus. Also provided are pharmaceutical compositions comprising the isolated protein or an adenoviral expression construct for delivery and expression of a nucleic acid encoding the isolated protein for prophylactic and/or therapeutic treatment of human cytomegalovirus infection, particularly in humans. 101/15 0 2 14 I P4H P4 CLV) 1~4i-1 c oo 0 C,) 0 >I Dhus~Of > Cy car34 a.( rN Cy p H0C W C0 HI 4 -0 E-.C P, , H 04. 0.o H *0 w. 1 0 . FIG.1I
