#$%^&*AU2020201184A120200305.pdf#####ABSTRACT A composition comprising a plurality of coated particles, wherein each of the coated particles comprises: a core particle comprising a pharmaceutical agent or a salt thereof； and a coating comprising a surface-altering agent surrounding the core particle, wherein the surface-altering agent comprises a synthetic polymer having pendant hydroxyl groups on the backbone of the polymer, the polymer having a molecular weight of at least about 1kDa and less than or equal to about 1000 kDa, wherein the polymer is at least about 30% hydrolyzed and less than about 95% hydrolyzed； and wherein the coated particles have a relative velocity of greater than 0.5 in mucus.1/116 A4 32h) IG I
