您的位置: 首页 > 农业专利 > 详情页

ANTI-P53 ANTIBODIES
专利权人:
Agency for Science, Technology and Research;Singapore Health Services Pte. Ltd.;National University of Singapore
发明人:
Tr Kanaga Sabapathy,David P. Lane,Le-Ann Hwang,Xin Yu Koh,Liew Oi Wah
申请号:
US16342763
公开号:
US20190248879A1
申请日:
2017.10.17
申请国别(地区):
US
年份:
2019
代理人:
摘要:
The invention relates to methods for producing an antibody which is specific for a mutant p53 polypeptide over wildtype p53 polypeptide, comprising using said mutant p53 polypeptide as an immunogen wherein said polypeptide comprises: (i) an antigen sequence, comprising an amino acid sequence of the mutant p53 polypeptide including the mutation and at least one amino acid immediately adjacent to the mutation, and (ii) a scaffold sequence for providing the antigen sequence in a solvent-accessible configuration, in particular wherein the scaffold sequence is thioredoxin. In the specific embodiments, antibodies against mutant p53 comprising R175H, R248Q or R273H are generated. Also disclosed are the uses of said antibodies for diagnosis, prognosis and stratification of patient groups and further encompasses the use of antibodies for imaging and treatment of cancer.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

意 见 箱

匿名:登录

个人用户登录

找回密码

第三方账号登录

忘记密码

个人用户注册

必须为有效邮箱
6~16位数字与字母组合
6~16位数字与字母组合
请输入正确的手机号码

信息补充