The United States of America; as Represented by the Secretary; Department of Health and Human Services
发明人:
Kwong, Peter D.,Graham, Barney S.,McLellan, Jason S.,Joyce, Michael Gordon,Kanekiyo, Masaru,Zhang, Baoshan,Boyington, Jeffrey,Georgiev, Ivelin Stefanov,Pancera, Marie,Soto, Cinque,Srivatsan, Sanjay,St
申请号:
AU2014243756
公开号:
AU2014243756B2
申请日:
2014.03.13
申请国别(地区):
AU
年份:
2018
代理人:
摘要:
Disclosed are Respiratory Syncytial Virus (RSV) antigens including a recombinant RSV F protein stabilized in a prefusion conformation. Also disclosed are nucleic acids encoding the antigens and methods of producing the antigens. Methods for generating an immune response in a subject are also disclosed. In some embodiments, the method is a method for treating or preventing a RSV infection in a subject by administering a therapeutically effective amount of the antigen to the subject.