problem: a connection, which is suitable as a positive modulator \u0430\u043b\u043b\u043e\u0441\u0442\u0435\u0440\u0438\u0447\u0435\u0441\u043a\u043e\u0433\u043e \u0440\u0435\u0446\u0435\u043f\u0442\u043e\u0440\u0430 d1 dopamine (d1 ram).solution: the present invention methods investigated compound which has good activity against \u0430\u043b\u043b\u043e\u0441\u0442\u0435\u0440\u0438\u0447\u0435\u0441\u043a\u043e\u0439 \u043c\u043e\u0434\u0443\u043b\u0438\u0440\u0443\u044e\u0449\u0435\u0439 dopamine receptor d1 and is suitable as an active ingredient of pharmaceutical compositions for the prevention and \/ or treatment of cognitive impairment. the negative symptoms of schizophrenia, parkinsons disease, alzheimers disease.huntingtons disease, dependence on medicines or the like, and thus, the authors found that the compound has \u0433\u0435\u0442\u0435\u0440\u043e\u0446\u0438\u043a\u043b\u0438\u0447\u0435\u0441\u043a\u043e\u0435 \u0430\u0446\u0435\u0442\u0430\u043c\u0438\u0434\u043d\u043e\u0435 polo \u0436\u0438\u0442\u0435\u043b\u044c\u043d\u043e\u0439 \u0430\u043b\u043b\u043e\u0441\u0442\u0435\u0440\u0438\u0447\u0435\u0441\u043a\u043e\u0439 \u043c\u043e\u0434\u0443\u043b\u0438\u0440\u0443\u044e\u0449\u0435\u0439 activity relative to the d1 dopamine receptor.according to the present invention has the \u0433\u0435\u0442\u0435\u0440\u043e\u0446\u0438\u043a\u043b\u0438\u0447\u0435\u0441\u043a\u043e\u0435 \u0430\u0446\u0435\u0442\u0430\u043c\u0438\u0434\u043d\u043e\u0435 positive \u0430\u043b\u043b\u043e\u0441\u0442\u0435\u0440\u0438\u0447\u0435\u0441\u043a\u043e\u0439 \u043c\u043e\u0434\u0443\u043b\u0438\u0440\u0443\u044e\u0449\u0435\u0439 activity relative to the \u0440\u0435\u0446\u0435 \u043f\u0442\u043e\u0440\u0443 d1 dopamine and may be used as an agent for the prevention and \/ or treatment of cognitive decline, the negative symptoms of schizophrenia, the disease pa \u0440\u043a\u0438\u043d\u0441\u043e\u043d\u0430, alzheimers disease, huntingtons disease,dependen
