Tick borne disease affect 80% of worlds cattle population and are widely distributed throughout the continents, particularly in the tropics and subtropics. Acaricide against cattle ixodid tick prepared using cow urine, neem oil and dishwashing soap (purchased from local market). The acaricide was sprayed on the body of cattle specifically on predilection site of ticks for vivo efficacy. The result obtained indicate that tick get paralyzed and killed within an hour of spraying, histological studies of cuticle before and after spraying also were carried out
