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DIHYDROTHIAZINE AND DIHYDROOXAZINE DERIVATIVES HAVING BACE1 INHIBITORY ACTIVITY
专利权人:
SHIONOGI and CO.; LTD.
发明人:
KUSAKABE, KEN-ICHI,TADANO, GENTA,KOMANO, KAZUO,FUCHINO, KOUKI,NAKAHARA, KENJI
申请号:
PH12016501891
公开号:
PH12016501891A1
申请日:
2016.09.26
申请国别(地区):
PH
年份:
2016
代理人:
摘要:
The present invention provides a compound which has an effect of inhibiting amyloid B production, especially an effect of inhibiting BACE1, and which is useful as a therapeutic or phylactic agent for diseases induced by production, secretion and/or deposition of amyloid B proteins. A compound of the formula (I) wherein X is -S- or -O-, R3a is alkyl, haloalkyl or the like, R2a is H, halogen, alkyloxy, haloalkyloxy or the like, R2b is H or the like, R3b is H or alkyl, ring A and ring B is each independently a substituted or unsubstituted aromatic carbocycle, a substituted or unsubstituted aromatic heterocycle or the like, and R1 is substituted or unsubstituted alkyl or the like, or a pharmaceutically acceptable salt thereof.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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