The present invention relates to compounds of formula wherein L is a bond, -C(O)NH-, -NHC(O)-, -CH2NHC(O)-, CH2C(O)NH-, -CH2NH-, -NH- or -NHC(O)NH-； R1 is hydrogen, lower alkyl, halogen, lower alkoxy-alkyl, lower alkoxy substituted by halogen, lower alkyl substituted by halogen or is phenyl or heteroaryl selected from the group consisting of pyridinyl, pyrimidinyl, pyrazinyl or pyrazolyl, and wherein phenyl and heteroaryl are optionally substituted by one, two or three substituents selected from the group consisting of halogen, lower alkyl, lower alkoxy, lower alkyl substituted by halogen, lower alkoxy substituted by halogen, cycloalkyl or O-CH2-cycloalkyl； or to a pharmaceutically suitable acid addition salt thereof, to all racemic mixtures, all their corresponding enantiomers and/or optical isomers, which may be used for the treatment of depression, anxiety disorders, bipolar disorder, attention deficit hyperactivity disorder (ADHD), stress-related disorders, psychotic disorders, schizophrenia, neurological diseases, Parkinson’s disease, neurodegenerative disorders, Alzheimer’s disease, epilepsy, migraine, hypertension, substance abuse, metabolic disorders, eating disorders, diabetes, diabetic complications, obesity, dyslipidemia, disorders of energy consumption and assimilation, disorders and malfunction of body temperature homeostasis, disorders of sleep and circadian rhythm, and cardiovascular disorders.本發明係關於下式化合物，其中L係鍵、-C(O)NH-、-NHC(O)-、-CH2NHC(O)-、CH2C(O)NH-、-CH2NH-、-NH-或-NHC(O)NH-；R1係氫、低碳數烷基、鹵素、低碳數烷氧基-烷基、經鹵素取代之低碳數烷氧基、經鹵素取代之低碳數烷基，或係苯基或選自由吡啶基、嘧啶基、吡嗪基或吡唑基組成之群之雜芳基，且其中苯基及雜芳基視情況經一個、兩個或三個選自由以下組成之群之取代基取代：鹵素、低碳數烷基、低碳數烷氧基、經鹵素取代之低碳數烷基、經鹵素取代之低碳數烷氧基、環烷基或O-CH2-環烷基；或係關於其醫藥上適宜之酸加成鹽，係關於所有外消旋混合物、所有其相應鏡像異構物及/或光學異構物，其可用於治療抑鬱症、焦慮性病症、雙極性病症、注意力不足過動症(ADHD)、壓力相關病症、精神病症、精神分裂症、神經疾病、帕金森氏病(Parkinson’s disease)、神經退化性病症、阿茲海默氏病(Alzheimer’s disease)、癲癇、偏頭痛、高血壓、藥物濫用、代謝病症、飲食病症、糖尿病、糖尿病併發症、肥胖、異常血脂症、能量損耗及同化病症、體溫穩定病症及功能失調、睡眠及晝夜節律病症及心血管病症。
