BACAC, MARINA,CLAUS, CHRISTINA,FERRARA KOLLER, CLAUDIA,KLEIN, CHRISTIAN,LANG, SABINE,LEVITSKI, VIKTOR,UMANA, PABLO
申请号：
CA3039430
公开号：
CA3039430A1
申请日:
2017.12.18
申请国别(地区):
CA
年份:
2018
代理人:
摘要：
The present application relates to combination therapies employing tumor targeted anti-CD3 bispecific antibodies and 4-1BB (CD137) agonists, in particular 4-1BBL trimer containing antigen binding molecules, the use of these combination therapies for the treatment of cancer and methods of using the combination therapies. The trimer CEA-4-1BBL (Figure IB) provides the highest tumor regression when combined with CEA CD3 TCB (See table 18).
