The present disclosure generally relates to the field of radiation treatment. More specifically, the present disclosure generally relates to methods and radiation treatment systems for generating a radiation treatment plan. According to one example embodiment, a method may comprise dividing (220) at least one dose characteristic related to a dose distribution for a ROI into a plurality of subintervals. The method may further comprise partitioning (230) the ROI into a plurality of different partitions based on the subintervals. All voxels of the ROI with values within the same subinterval are partitioned into the same partition. For each of the plurality of different partitions, the method may comprise establishing (240) a weight and specifying (250) an optimization function for an obtainable dose distribution based on the respective subinterval of dose characteristics. The method may further comprise generating (260) the radiation treatment plan based on said established weights and specified optimization functions.
