PEPTIDE FOR IMMUNIZATION, METHOD FOR PRODUCING PEPTIDE FOR IMMUNIZATION, PHARMACEUTICAL COMPOSITION FOR IMMUNE DISEASES COMPRISING THE SAME, AND METHOD FOR TREATING IMMUNE DISORDERS
PROBLEM TO BE SOLVED: To provide novel peptides for immunization that can induce the antibody production against the complex of a peptide for immunization and the MHC molecule in a living body.SOLUTION: Provided is a peptide for immunization, including the T cell epitope of a target protein and an antibody induction part, the antibody induction part being, in the amino acid sequence of the target protein, at least one of one or more amino acid sequences continuous upstream from the N-terminal amino acid of the T cell epitope, or one or more amino acid sequences continuous downstream from the C-terminal amino acid of the T cell epitope, the peptide for immunization inducing the antibody production against a complex of the peptide for immunization and the MHC molecule in a living body by being administered to the living body.SELECTED DRAWING: Figure 5COPYRIGHT: (C)2020,JPO&INPIT【課題】免疫用ペプチドと生体のＭＨＣ分子との複合体に対する抗体産生を誘導できる新たな免疫用ペプチドを提供する。【解決手段】本発明の免疫用ペプチドは、免疫用ペプチドであって、前記免疫用ペプチドは、ターゲットタンパク質のＴ細胞エピトープと抗体誘導部とを含み、前記抗体誘導部は、前記ターゲットタンパク質のアミノ酸配列において、前記Ｔ細胞エピトープのＮ末端アミノ酸から上流側に連続する１以上のアミノ酸配列、および前記Ｔ細胞エピトープのＣ末端アミノ酸から下流側に連続する１以上のアミノ酸配列の少なくとも一方であり、前記免疫用ペプチドは、生体に投与することで、前記免疫用ペプチドと前記生体のＭＨＣ分子との複合体に対する抗体産生を誘導することを特徴とする。【選択図】図５
