NILSSON SUSAN KAYE,HAYLOCK DAVID NORMAN,CAO BENJAMIN BEN MING
申请号：
IN201717020261
公开号：
IN201717020261A
申请日:
2017.06.09
申请国别(地区):
IN
年份:
2017
代理人:
摘要：
in vivoex vivoin vivoex vivoHaematopoietic stem cell mobilization is a process whereby haematopoietic stem cells are stimulated out of the bone marrow space. Before HSC can mobilize they must be dislodged and released from the BM stem cell niche in which they reside and are retained by adhesive interactions. Accordingly in an aspect of the present invention there is provided a method for enhancing dislodgement of HSC and their precursors and progenitors thereof from a BM stem cell binding ligand or said method comprising administering or an effective amount of an antagonist of an a9 integrin or an active portion thereof and a CXCR4 antagonist or an active portion thereof to the BM stem cell niche. Once mobilized to the peripheral blood (PB) the HSC may be collected for transplant. Methods which enhance mobilization of the HSC can also improve treatments of haematological disorders.
