Compositions for delaying or delaying the onset of flail, reversing the aging phenotype, prolonging healthy lifespan, compressing morbidity, prolonging lifespan, and reducing the formation of senescent cells are provided herein. It is described in. [Selection diagram] Fig. 11Aフレイルの発症を遅らせるかまたはその進行を遅らせ、老化表現型を逆転し、健康寿命を伸ばし、病的状態を圧縮し、寿命を伸ばし、老化細胞の形成を減少させるための組成物が本明細書に記載される。【選択図】図11A