Disclosed is a therapeutic formulation suitable for intravenous administration to a subject comprising: an aqueous solution a hydrophobic active agent a dispersion stabilizing agent and an opsonization reducer wherein the hydrophobic active agent is Coenzyme Q10 (CoQ10) wherein the dispersion stabilizing agent is Dimyristoylphosphatidyl choline (DMPC) and wherein the hydrophobic active agent is dispersed into a colloidal nano-dispersion of particles having a mean size of between about 10-nm and about 100-nm.