BURKE, ELLEN,HICKS, PAULA M.,LUGINBUHL, PETER,RICHARDSON, TOBY,WEINER, DAVID P.,ZHAO, LISHAN
申请号：
ES07758102
公开号：
ES2383767T3
申请日:
2007.03.07
申请国别(地区):
ES
年份:
2012
代理人:
摘要：
An isolated, synthetic or recombinant nucleic acid comprising (a) a nucleic acid encoding at least one polypeptide, wherein the nucleic acid comprises a sequence having at least 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99% or more or 100% of sequence identity with respect to the sequence of SEQ ID NO: 275 in the total length of a cDNA, transcript (mRNA) or gene, wherein the nucleic acid encodes at least one polypeptide having an aldolase activity or encodes a polypeptide or peptide that acts as an epitope or immunogen and is capable of generating an aldolase specific antibody； (b) a nucleic acid encoding at least one polypeptide, wherein the nucleic acid comprises a sequence that is hydrated under stringent conditions with the complement of a nucleic acid comprising the sequence of SEQ ID NO: 275, wherein the nucleic acid encodes at least one polypeptide that has an aldolase activity or encodes a polypeptide or peptide that acts as an epitope or immunogen and is capable of generating an aldolase specific antibody； (c) a nucleic acid encoding at least one polypeptide having an aldolase activity, wherein the polypeptide comprises the sequence of SEQ ID NO: 276 or enzymatically active fragments thereof； (d) the nucleic acid of (a), (b) or (c) that encodes a polypeptide that has an aldolase activity but lacks a signal sequence, (e) the nucleic acid of (a), (b) , (c) or (d) encoding a polypeptide having an aldolase activity that further comprises a heterologous sequence； or (f) a nucleic acid sequence complementary to the nucleic acid of (a), (b), (c), (d) or (e). <；l id>； = "10000" level>； = "2" type>； = "1".Un ácido nucleico aislado, sintético o recombinante que comprende (a) un ácido nucleico que codifica al menos un polipéptido, en donde el ácido nucleico comprende una secuencia que tiene al menos 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99% o más o 100
