GRAY, NATHANAEL S.,ZHANG, TINGHU,HATCHER, JOHN,BUHRLAGE, SARA JEAN
申请号：
CA3042731
公开号：
CA3042731A1
申请日:
2017.11.22
申请国别(地区):
CA
年份:
2018
代理人:
摘要：
The present invention provides novel compounds of Formula (I'), and pharmaceutically acceptable salts, solvates, hydrates, polymorphs, co-crystals, tautomers, stereoisomers, isotopically labeled derivatives, prodrugs, and compositions thereof. Also provided are methods and kits involving the inventive compounds or compositions for treating and/or preventing proliferative diseases (e.g., cancers (e.g., leukemia, lymphoma)), inflammatory diseases, autoinflammatory diseases, and autoimmune diseases in a subject. Treatment of a subject with a proliferative disease using a compound or composition of the invention may inhibit the aberrant activity of a kinase, such as an interleukin-1 receptor-associated kinase (IRAK) (e.g., IRAKI and/or IRAK4) in the subject.
