Shows a controlled release active ingredient (A) is pharmacologically was embedded in a matrix containing the polymer (C) relates to a pharmaceutical dosage form a heated melt extrusion molding, the present invention, the dosage form, shows the breaking strength of 300N at least, oval, including a peripheral between the rear and the front and side, after the perpendicular, the extension of laterally extending in the longitudinal direction, for the stretch in the longitudinal direction, the front side, facing The shaped core of the pharmaceutical dosage form is caused by heat melt extrusion molding, and it has a morphological direction is substantially perpendicular to the longitudinal extension of the dosage form / or active components (A), the release per area through the side is faster than the release of the peripheral edge through after opposing front and pharmacologically.本発明は、ポリマー(C)を含むマトリックス中に包埋させた薬理学的に活性な成分(A)の制御放出を示す、加熱溶融押出成型した医薬投与剤型に関し、前記投与剤型は、少なくとも300Nの破壊強度を示し、長手方向の伸長、長手方向の伸長に対して直角の、横方向の伸長、前側、向かい合う後側、および前記前側と後側との間の周縁を含む楕円形の形状を有し、医薬投与剤型のコアが、加熱溶融押出成型により引き起こされた、投与剤型の長手方向の伸長に対して実質的に直角である形態学的方向性を有し、かつ/または薬理学的に活性な成分(A)の、前側および向かい合う後側を通しての面積当たりの放出が、周縁を通しての放出よりも速い。
