Jonathan B. Rothbard,Paul A. Wender,Leo P. McGrane,Lalitha V.S. Sista,Thorsten A. Kirschberg
申请号：
US14140223
公开号：
US20140213532A1
申请日:
2013.12.24
申请国别(地区):
US
年份:
2014
代理人:
摘要：
This invention provides compositions and methods for enhancing delivery of drugs and other agents across epithelial tissues, including the skin, gastrointestinal tract, pulmonary epithelium, ocular tissues and the like. The compositions and methods are also useful for delivery across endothelial tissues, including the blood brain barrier. The compositions and methods employ a delivery enhancing transporter that has sufficient guanidine or amidino sidechain moieties to enhance delivery of a compound conjugated to the reagent across one or more layers of the tissue, compared to the non-conjugated compound. The delivery-enhancing polymers include, for example, poly-arginine molecules that are preferably between about 6 and 25 residues in length.
