Corte, James R.,De Lucca, Indawati,Fang, Tianan,Yang, Wu,Wang, Yufeng,Dilger, Andrew K.,Pabbisetty, Kumar Balashanmuga,Ewing, William R.,Zhu, Yeheng,Wexler, Ruth R.,Pinto, Donald J. P.,Orwat, Michael
申请号：
AU2019216617
公开号：
AU2019216617A1
申请日:
2019.08.13
申请国别(地区):
AU
年份:
2019
代理人:
摘要：
#$%^&*AU2019216617A120190905.pdf#####ABSTRACT The present invention provides compounds of Formula (I): X Y 0 B R7 N R~AA G1 N or stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, wherein all the 5 variables are as defined herein. These compounds are selective factor XIa inhibitors or dual inhibitors of FXIa and plasma kallikrein. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating thromboembolic and/or inflammatory disorders using the same.
