KHALIL, DANNY NEJAD,WOLCHOK, JEDD D.,MERGHOUB, TAHA
申请号：
CA2994965
公开号：
CA2994965A1
申请日:
2016.08.08
申请国别(地区):
CA
年份:
2017
代理人:
摘要：
The present invention provides various compositions and methods useful for the treatment of cancer, such as cancers that are resistant to immune checkpoint blockade and/or are resistant to treatment with PD-1, PD-L1 or CTLA-4 inhibitors. In some embodiments the present invention provides compositions comprising one or more CD40 agonists (e.g. CD40 agonist antibodies), TLR agonists, and/or IL10 receptor inhibitors or IL10 inhibitors, and/or various combinations thereof, optionally together with one or more immune checkpoint inhibitors, and the use of such compositions in treatment of tumors.
